Prevalence and Associated Risk Factors for Venous Thromboembolism in a Large Cohort of Patients With Cushing Disease
Authors' conclusion
The findings of this study confirm a high prevalence of VTE events in patients with CD, irrespective of the surgical period. Risk factors associated with a higher likelihood of VTE include obesity, severity of hypercortisolism, and the occurrence of postoperative complications. In this patient population, thromboprophylaxis should be considered.
Study context
- Population
- Patients with Cushing disease (CD) at a tertiary care center; controls with clinically nonfunctioning pituitary macroadenomas undergoing similar surgery
- Participants
- 408 vs 323
- Exposure
- CD vs clinically nonfunctioning pituitary adenomas
- CDn = 408
- Nonfunctioning pituitary adenoman = 323reference
- Outcome
- Prevalence of VTE
Methodological detailssingle-centre, tertiary care center, control group of nonfunctioning pituitary macroadenomas
- Single-centre
- Tertiary care center
- Control group of nonfunctioning pituitary macroadenomas
Main finding
As reported in the abstract
VTE events
P < 0.001
Observational data: associations, not effects.
Further findings
Timing of venous thromboembolism (VTE) events · preoperative period
- VTE events occurring in the preoperative period
- 54%
Risk factors for VTE (logistic regression)
- Significant risk factors: obesity, mood disorders, supraclavicular fossa fullness, leukopenia or leukocytosis, elevated serum and 24-hour urinary cortisol, postoperative complications (infections, cerebrospinal fluid leak, AVP deficiency)
Original publication
Prevalence and Associated Risk Factors for Venous Thromboembolism in a Large Cohort of Patients With Cushing Disease. Endocr Pract. Published 15 October 2025. doi:10.
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