Circulating miR-20a-5p as a biomarker associated with cabergoline responsiveness in patients with hyperprolactinemia and pituitary adenomas
Authors' conclusion
Circulating miR-20a-5p is a potential biomarker for prolactinoma, which could be associated with responsiveness to DAs.
Study context
- Population
- Patients with hyperprolactinemia and pituitary tumors; validation cohort of 247 patients with hyperprolactinemia and 37 controls247 patients · 37 controls
- Comparison
- Prolactinoma vs nonfunctioning pituitary adenoma (NFPA); before vs after cabergoline
- Outcome
- Circulating miRNA candidates and miR-20a-5p expression
Methodological detailsbiomarker discovery and validation, nCounter profiling with quantitative reverse transcription-polymerase chain reaction (qRT-PCR) validation, cell-line experiments
- Biomarker discovery and validation
- nCounter profiling with qRT-PCR validation
- Cell-line experiments
Main finding
As reported in the abstract
- Three miRNA candidates selected (miR-20a-5p, miR-424-5p, miR-514a-5p)
- 3
Original publication
Circulating miR-20a-5p as a biomarker associated with cabergoline responsiveness in patients with hyperprolactinemia and pituitary adenomas. Eur J Endocrinol. Published 2 April 2025. doi:10.
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