Autoimmune Disorders Associated With Surgical Remission of Cushing’s Disease : A Cohort Study
Main finding · Cumulative incidence of new-onset autoimmune diseaseResult — go to the resultHazard ratio 7.80 CI 2.88–21.10Authors' conclusion
Patients achieving surgical remission of CD have higher incidence of autoimmune disease than age- and sex-matched patients with NFPAs. Family history of autoimmune disease is a potential risk factor. Adrenal insufficiency may be a trigger.
Study context
- Population
- Patients with Cushing's disease (CD) with surgical remission and surgically treated NFPA; academic medical center/pituitary centermatched cohort
- Exposure
- CD with surgical remission vs surgically treated NFPA
- Outcome
- Cumulative incidence of new-onset autoimmune disease
- Follow-up
- 3 years after surgery
Methodological detailsage- and sex-matched, single academic medical center/pituitary center
- Age- and sex-matched
- Single academic medical center/pituitary center
Main finding
As reported in the abstract
Hazard ratio
7.80
CI 2.88–21.10
By group
CDvs NFPAs
HR 7.80 (CI 2.88–21.10)
Observational data: associations, not effects.
Further findings
Postoperative adrenal insufficiency
Postoperative nadir serum cortisol
Within CD: autoimmune disease vs no autoimmune disease — preoperative 24-hour urine free cortisol (UFC) ratio and family history of autoimmune disease
- Preoperative 24-hour UFC ratio, CD with vs without autoimmune disease
- 2.7 vs. 6.3
- Family history of autoimmune disease, CD with vs without autoimmune disease
- 41.2% vs. 20.9%
Original publication
Autoimmune Disorders Associated With Surgical Remission of Cushing’s Disease : A Cohort Study. Ann Intern Med. Published 20 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →