Speckle-tracking echocardiography reveals the synergistic impact of GH/IGF-1 excess and metabolic dysregulation on cardiac dysfunction in acromegaly
Authors' conclusion
Subclinical cardiac dysfunction in acromegaly is driven by IGF-1, exacerbated by metabolic factors, and improved with remission. STE supports early risk stratification and integrated management.
Study context
- Population
- Patients with acromegaly evaluated by speckle-tracking echocardiography (STE)39 females
- Participants
- 74 patients
- Outcome
- Subclinical myocardial dysfunction by STE (global longitudinal strain (GLS), LV systolic dyssynchrony, global wasted work, global work efficiency) and its associations with disease activity, metabolic parameters and treatment status
Main finding
As reported in the abstract
- Correlation of IGF-1 z-score with IVS thickness
- r = 0.564
- Correlation of IGF-1 z-score with LVPW thickness
- r = 0.431
- Correlation of IGF-1 z-score with left ventricular systolic dyssynchrony (LVSD)
- r = 0.359
- Correlation of IGF-1 z-score with global work efficiency (GWE) (all p < 0.01)
- r = - 0.361
- IGF-1 z-score independent predictor of LVPW thickness (p = 0.045)
- β = 0.210
- IGF-1 z-score independent predictor of LVSD index (p = 0.048)
- β = 2.249
Observational data: associations, not effects.
Further findings
Sex differences
- Males had higher IGF-1, BMI and more pronounced cardiac alterations than females (all p < 0.05)
Treatment status
- Biochemical remission: superior cardiac structure and function vs untreated/active (p < 0.05)
Original publication
Speckle-tracking echocardiography reveals the synergistic impact of GH/IGF-1 excess and metabolic dysregulation on cardiac dysfunction in acromegaly. Pituitary. Published 29 May 2026. doi:10.
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