Thyroid disease

Evaluation of Cardiac Autonomic Function in Patients With Alteration in Thyroid Hormones: Systematic Literature Review

Clin Endocrinol (Oxf)Published Systematic review

Authors' conclusion

Both hypothyroidism and hyperthyroidism affect cardiac autonomic modulation, resulting in a reduction in heart rate variability. However, there were differences in relation to the availability of frequency and time data.

Study context

Population
Humans with thyroid hormone diseases (hypothyroidism or hyperthyroidism) in experimental studies analysing heart rate variability15 studies
Outcome
Heart rate variability
Methodological detailsno date restrictions, Searched Virtual Health Library (VHL), Scielo, Pubmed via Medline, Cochrane, Embase, Scopus, Web of Science, Cinahl and SPORTDiscus, 10298 items found; 15 non-randomised clinical trials included
  • No date restrictions
  • Searched VHL, Scielo, Pubmed via Medline, Cochrane, Embase, Scopus, Web of Science, Cinahl and SPORTDiscus
  • 10298 items found; 15 non-randomised clinical trials included

Pooled result

As reported in the abstract

  • Patients with hypothyroidism or hyperthyroidism have reduced heart rate variability, reflecting decreased adaptive capacity of the heart

Original publication

Evaluation of Cardiac Autonomic Function in Patients With Alteration in Thyroid Hormones: Systematic Literature Review. Clin Endocrinol (Oxf). Published 3 July 2025. doi:10.1111/cen.15299

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