Chronic Kidney Disease and Thyroid Hormones
Authors' conclusion
This large-scale cohort study demonstrates that hypothyroidism accelerates CKD progression, while both hypo- and hyperthyroidism increase mortality risk in CKD patients. THRT appears to attenuate the adverse effects of hypothyroidism on renal function. Regular thyroid function monitoring and appropriate THRT should be considered in CKD management.
Study context
- Population
- Chronic Kidney Disease (CKD) patients, China Renal Data System
- Participants
- 30,804 patients
- Exposure
- Hypothyroidism and hyperthyroidism vs normal thyroid function; Thyroid hormone replacement therapy (THRT) in hypothyroid patients
- Normal thyroid functionn = 26,673reference
- Hypothyroidismn = 2,291
- Hyperthyroidismn = 1,840
- Outcome
- Composite:
- Renal failure
- All-cause mortality
Main finding
As reported in the abstract
Each group vs normal thyroid functionEstimate (95% CI)P value
Hypothyroidism
aHR (renal failure) 1.29(1.15–1.45)
P < 0.001Hypothyroidism
aHR (all-cause mortality) 1.24(1.11–1.39)
P < 0.001Hyperthyroidism
aHR (all-cause mortality) 1.20(1.07–1.33)
P < 0.01Observational data: associations, not effects.
Secondary outcomes
Renal failure with THRT in hypothyroid patients
| aHR (95% CI) | P value | ||
|---|---|---|---|
| THRT | 0.65 (0.52–0.82) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Chronic Kidney Disease and Thyroid Hormones. J Clin Endocrinol Metab. Published 9 December 2024. doi:10.
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