Performance of Afirma Genomic Sequencing Classifier in Binary Subcategories of Atypia of Undetermined Significance Thyroid Nodules: Single Versus Repeat Diagnosis
Authors' conclusion
GSC BCR and diagnostic performance of GSC testing may vary in AUS-N versus AUS-O subcategories. However, there were no statistically significant differences in GSC performance between single and repeat AUS cohorts.
Study context
- Population
- Thyroid nodules with a single or repeat atypia of undetermined significance (AUS) diagnosis on fine-needle aspiration and a diagnostic Genomic Sequencing Classifier (GSC) result (benign vs suspicious), followed by surgery or ≥12 months of clinical and/or US monitoring
- Participants
- 365 thyroid nodules
- Comparison
- GSC performance in AUS-N vs AUS-O, and single vs repeat AUS cohorts
- AUS-Nn = 106
- AUS-On = 259reference
- Outcome
- Performance of GSC testing in AUS-N vs AUS-O subcategories and between single and repeat AUS cohorts
Methodological detailsconsecutive nodules
- Consecutive nodules
Performance
As reported in the abstract
GSC benign call rate (BCR)
- AUS-N vs AUS-O: P = 0.001
- AUS-N vs AUS-O: P = 0.02
Further findings
| Outcome | P value |
|---|---|
| Histology-proven malignancy with suspicious GSC resultAUS-N vs AUS-O · single AUS: 28% vs 10%; tended to be greater with AUS-N | P = 0.09 |
| Histology-proven malignancy with suspicious GSC resultAUS-N vs AUS-O · repeat AUS: 38% vs 27%; tended to be greater with AUS-N | P = 0.3 |
| Specificity, single AUS cohort73% vs 51%; higher with AUS-O | P = 0.01 |
Repeat vs single AUS cohort performance
- In both subcategories, repeat AUS cohort had greater specificity, PPV and diagnostic accuracy than single AUS; differences not statistically significant
Original publication
Performance of Afirma Genomic Sequencing Classifier in Binary Subcategories of Atypia of Undetermined Significance Thyroid Nodules: Single Versus Repeat Diagnosis. Thyroid. Published 4 December 2024. doi:10.
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