Relationship Between Serum Thyrotropin Levels and Metabolic Diseases in Older Adults
Authors' conclusion
Slightly elevated TSH levels are not associated with an increased risk of metabolic diseases in older adults. Therefore, we recommend raising the upper limit of the TSH range for individuals aged 65 years and older.
Study context
- Population
- Older (≥65 years) and young (18–64 years) adults from general communities in mainland China, excluding overt hyperthyroidism or overt hypothyroidism; each age group divided into 4 TSH groups6,791 older, 55,303 young
- Exposure
- TSH categories vs euthyroid in older adults
- Outcome
- Anthropometric assessments, serum thyroid functions and metabolic parameters
Methodological detailsnationally representative, 31 provinces in mainland China
- Nationally representative
- 31 provinces in mainland China
Main finding
As reported in the abstract
Metabolic disorders in older adults
TSH >8.86 mU/L vs EuthyroidOdds ratio (95% CI)
Low HDL-C; adjusted
1.84(1.14–2.98)
Dyslipidemia; adjusted
1.49(1.09–2.04)
Observational data: associations, not effects.
Original publication
Relationship Between Serum Thyrotropin Levels and Metabolic Diseases in Older Adults. J Clin Endocrinol Metab. Published 2 July 2024. doi:10.
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