No causal associations of genetically predicted birth weight and life course BMI with thyroid function and diseases
Authors' conclusion
Our comprehensive MR did not find causal links of birth weight, childhood BMI, or adulthood BMI with thyroid diseases but provided evidence that thyroid cancer may play a role in weight gain. Our research findings offer valuable insights into the intricate relationship between body weight and thyroid health throughout an individual's life.
Study context
- Population
- GWAS meta-analyses predominantly of individuals of European ancestry
- Comparison
- Genetically predicted birth weight, childhood BMI and adulthood BMI vs thyroid function and diseases
- Outcome
- TSH levels, hypothyroidism, hyperthyroidism, autoimmune thyroid disorders and thyroid cancer
Methodological detailsreverse Mendelian randomization (MR) analysis on adulthood BMI
- Reverse MR analysis on adulthood BMI
Main finding
As reported in the abstract
Causal associations of birth weight and life course BMI with thyroid outcomes
- No evidence of causal associations of birth weight or BMI at different life stages with TSH levels, hypothyroidism, hyperthyroidism, autoimmune thyroid disorders or thyroid cancer
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| Reverse MR: thyroid cancer → adulthood BMIIncreased adulthood BMI | 0.010 (0.006–0.015) | P = 5.21 × 10-6 |
Original publication
No causal associations of genetically predicted birth weight and life course BMI with thyroid function and diseases. Obesity (Silver Spring). Published 2 July 2024. doi:10.
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