Prevalence of Thyroid Nodules in Residents of Ukraine Exposed as Children or Adolescents to Iodine-131 from the Chornobyl Accident
Authors' conclusion
Childhood exposure to I-131 is associated with an increased risk of thyroid nodules detected 12-14 years following exposure, and the risk for neoplastic nodules is higher than for non-neoplastic nodules.
Study context
- Population
- Residents of Ukraine aged <18 years at the Chornobyl accident (April 26, 1986), screened 1998–2000; median age 21.5 years; mean dose 0.53 Gy (range 0.0003–31 Gy)13,078 eligible
- Participants
- 13,243 residents
- Exposure
- Childhood I-131 thyroid dose
- Outcome
- Prevalence of US-detected thyroid nodules overall and by histology/cytology, size and number
Methodological detailscohort-based ultrasound screening, Screening conducted 1998-2000; EOR/Gy estimated by logistic regression
- Cohort-based ultrasound screening
- Screening conducted 1998-2000; EOR/Gy estimated by logistic regression
Main finding
As reported in the abstract
≥1 thyroid nodule
Individuals with ≥1 thyroid nodule
358
2.7%
EOR/Gy, neoplastic nodules (doses <5 Gy)
5.35; CI: 2.19-15.5
EOR/Gy, non-neoplastic nodules (doses <5 Gy)
0.24; CI: 0.07-0.74
Observational data: associations, not effects.
Original publication
Prevalence of Thyroid Nodules in Residents of Ukraine Exposed as Children or Adolescents to Iodine-131 from the Chornobyl Accident. Thyroid. Published 26 June 2024. doi:10.
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