Birth weight and placental weight in children born to mothers with hypothyroidism
Authors' conclusion
The findings from a large Danish cohort point toward an association between hypothyroidism in pregnancy and lower birth weight of the child, whereas no association with placental weight was found.
Study context
- Population
- Singleton live births in Denmark, 2004–2015
- Participants
- 694,734 births
- Exposure
- Maternal hypothyroidism vs no hypothyroidism
- Outcome
- Birth weight (small for gestational age (SGA) <10th percentile, large for gestational age (LGA) >90th percentile) and placental weight Z-score, by gestational week and sex
- Follow-up
- Birth
Methodological detailsnationwide register-based, adjusted for potential confounders incl. maternal body mass index (BMI)
- Nationwide register-based
- Adjusted for potential confounders incl. maternal BMI
Main finding
As reported in the abstract
SGA
Each group vs no hypothyroidismAdjusted odds ratio (95% CI)
Newly diagnosed hypothyroidism
1.16(1.00–1.34)
Treated hypothyroidism
0.94(0.86–1.03)
Observational data: associations, not effects.
Further findings
| Outcome | Newly diagnosed hypothyroidism | No hypothyroidism | aOR (95% CI) | |
|---|---|---|---|---|
| LGANewly diagnosed hypothyroidismvs No hypothyroidism | 9.3% | 9.9% | 1.03 (0.87–1.21) | |
| LGATreated hypothyroidismvs No hypothyroidism | 1.06 (0.98–1.14) | |||
| 0.512Adjusted odds ratio (log scale) |
| Outcome | Adjusted beta coefficient (95% CI) |
|---|---|
| Placental weight Z-scoreMaternal hypothyroidism vs No hypothyroidism · no association | 0.004 (−0.016 to 0.024) |
Original publication
Birth weight and placental weight in children born to mothers with hypothyroidism. Eur Thyroid J. Published 26 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →