Obesity

Effects of non‐nutritive sweetened beverages versus water after a 12‐week weight‐loss program: A randomized controlled trial

Obesity (Silver Spring)Published Randomised controlled trial

Primary result · Weight changeResult — go to the resultDifference −0.2 kg 90% CI −0.7 to 0.4

Authors' conclusion

Weight loss was equivalent with NNS beverages and water following a 12-week behavioral weight-management program.

Study context

Population
Adults with BMI 27 to 35 kg/m² who regularly drank cold beverages, undergoing a weekly 12-week group behavioral weight-management program; 24.1% non-nutritive sweetened (NNS) beverage naïverandomized 1:1
Participants
493 adults
Comparison
NNS beverages vs water during a 12-week behavioral weight-management program
  • NNS beveragesn = 247
  • Watern = 246reference
Primary endpoint
Weight change (equivalence: two-sided p > 0.05)
Follow-up
Week 12
Methodological detailsongoing 2-year, parallel-group, open-label, controlled equivalence trial, week-12 data reported
  • Ongoing 2-year
  • Parallel-group
  • Open-label
  • Controlled equivalence trial
  • week-12 data reported

Primary result

Weight change

Difference

−0.2 kg

90% CI −0.7 to 0.4

Change by group

NNS beverages

−5.8

kg

Water

−5.6

kg

NNS beveragesvs Water
difference −0.2 kg (90% CI −0.7 to 0.4)

As reported in the abstract

Secondary outcomes

Waist circumference reduction · week 12

Reduction in waist circumference greater with NNS beverages vs water

HbA1c and sweetener consumption reduction · week 12

Reductions in HbA1c and consumption of any type of sweetener greater with water vs NNS beverages

Other secondary end points · week 12

No significant differences between groups for other secondary end points (hip circumference, blood pressure, lipids, liver function, hunger, activity)

Original publication

Effects of non‐nutritive sweetened beverages versus water after a 12‐week weight‐loss program: A randomized controlled trial. Obesity (Silver Spring). Published 21 July 2023. doi:10.1002/oby.23796

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