Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery
Authors' conclusion
Bariatric surgery patients display a unique B cell profile 6 months post-operatively; this bears minimal resemblance to that of pre-operative patients and only partially overlaps with that of lean controls. Post-operative differences in the B cell compartment compared to lean controls are detected despite global amelioration of inflammation and restoration of metabolic health. Collectively, this indicates that bariatric surgery creates a specific immunometabolic state with potential implications for health outcomes.
Study context
- Population
- Individuals with obesity (BMI ≥35 kg/m²) undergoing bariatric surgery and age- and sex-matched lean controls
- Participants
- 21 / 17 / 18
- Comparison
- Obesity pre- and 6 months post-bariatric surgery vs lean controls
- Pre-operativen = 21
- Post-operativen = 17
- Lean controlsn = 18reference
- Outcome
- Peripheral blood B cell composition (immunophenotyping) and association with inflammatory and metabolic parameters
- Follow-up
- Before and 6 months after surgery
Methodological detailsprospective follow-up, age- and sex-matched lean controls
- Prospective follow-up
- Age- and sex-matched lean controls
Main finding
As reported in the abstract
Peripheral blood B cell composition
- In obesity, expansion of naïve and reduction in total memory B cells
- 6 months after bariatric surgery the naïve/memory B cell balance is restored
- Post-operative patients uniquely show increased CD11c+CXCR5-IgD-CD27- DN2 B cells and CD27+CD38++ plasmablasts
- Correlations between B cell subsets, inflammatory and metabolic parameters were distinct in lean, pre- and post-operative individuals
Original publication
Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery. Int J Obes (Lond). Published 18 July 2023. doi:10.
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