Metabolomic Profiles Associated With Sugary Beverage Intakes in Youth
Authors' conclusion
SSB and 100% fruit juice intake are associated with largely distinct metabolomic profiles, suggesting some degree of beverage-specific metabolic effects in youth.
Study context
- Population
- Youth in the EPOCH cohort, assessed in childhood (6–14 years) and adolescence (12–19 years)
- Participants
- 593 participants
- Exposure
- SSB vs 100% fruit juice intake
- Outcome
- Metabolites associated with each beverage, consistently selected across both visits
- Follow-up
- Childhood and adolescence
Methodological detailsuntargeted metabolomics profiling, Least Absolute Shrinkage and Selection Operator (LASSO) regression with bootstrapping
- Untargeted metabolomics profiling
- LASSO regression with bootstrapping
Main finding
As reported in the abstract
Metabolites associated with intake at both visits (of 767 metabolites)
| Group | Value | Amino acid metabolism | Xenobiotic metabolism | Lipid metabolism | Carbohydrate metabolism |
|---|---|---|---|---|---|
| SSB | 40 metabolites | 10 | 11 | 8 | 1 |
| Fruit juice | 39 metabolites | 7 | 8 | 8 | 3 |
Value
SSB40 metabolites
Fruit juice39 metabolites
Amino acid metabolism
SSB10
Fruit juice7
Xenobiotic metabolism
SSB11
Fruit juice8
Lipid metabolism
SSB8
Fruit juice8
Carbohydrate metabolism
SSB1
Fruit juice3
- Metabolites associated with both SSB and fruit juice intake (argininate, cortisone, quinate); all others unique
- 3
Observational data: associations, not effects.
Further findings
Beverage intake · childhood; adolescence
Original publication
Metabolomic Profiles Associated With Sugary Beverage Intakes in Youth. Pediatr Obes. Published 14 July 2026. doi:10.
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