Gestational diabetes & diabetes in pregnancy
Effect of Breastfeeding Duration on Coagulation in Women With and Without History of Gestational Diabetes Mellitus
Authors' conclusion
Longer duration of breastfeeding is associated with lower CV risk and an improved coagulation profile. Women with GDM history appear to benefit particularly from prolonged breastfeeding.
Study context
- Population
- Participants of the German Gestational Diabetes Study (PREG), examined 14 months (IQR 12–26 months) after delivery with 5-point OGTT
- Participants
- 76 participants
- Exposure
- Breastfeeding duration in women with vs without history of gestational diabetes mellitus (GDM)
- Outcome
- Effect of breastfeeding duration on plasmatic coagulation (global coagulation tests, prothrombotic and antithrombotic proteins, endothelial markers)
- Follow-up
- 14 months (IQR, 12-26 months) after delivery
Methodological detailssecondary analysis of the PREG study, multivariable linear models
- Secondary analysis of the PREG study
- Multivariable linear models
Main finding
As reported in the abstract
Association of breastfeeding duration with coagulation
- Overall, longer breastfeeding negatively associated with FIX
- P = .018
- Interaction between previous GDM and breastfeeding duration for FIX
- PInteraction = .017
- Only in women with GDM history, breastfeeding duration negatively associated with FIX activity; persisted after adjustment for age, BMI, insulin sensitivity and C-reactive protein
- P = .016
Observational data: associations, not effects.
Further findings
10-year CV risk (Framingham risk score)
- Longer breastfeeding associated with lower CV risk
- P = 0.05
Original publication
Effect of Breastfeeding Duration on Coagulation in Women With and Without History of Gestational Diabetes Mellitus. J Clin Endocrinol Metab. Published 15 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →