Differences in Inflammatory Pathways Between Dutch South Asians vs Dutch Europids With Type 2 Diabetes
Authors' conclusion
South Asian patients with T2D show a more activated IFN-signaling pathway compared to Europid patients with T2D, which is more pronounced in women than men. We speculate that a more activated IFN-signaling pathway may contribute to the more rapid progression of T2D in South Asian compared with Europid individuals.
Study context
- Population
- Dutch South Asian and Dutch Europid patients with T2D
- Participants
- 45 vs 44
- Comparison
- Dutch South Asian vs Dutch Europid patients with T2D
- South Asiansn = 45
- Europidsn = 44reference
- Primary endpoint
- mRNA transcripts of 182 immune genes (microfluidic quantitative PCR) in fasted whole-blood; ingenuity pathway analyses
Primary result
As reported in the abstract
Higher messenger RNA (mRNA) levels of B-cell markers (CD19, CD79A, CD79B, CR2, CXCR5, IGHD, MS4A1, PAX5) in South Asians
all fold change > 1.3, false discovery rate [FDR] < 0.008
Higher Interferon (IFN)-signaling genes (CD274, GBP1, GBP2, GBP5, FCGR1A/B/CP, IFI16, IFIT3, IFITM1, IFITM3, TAP1) in South Asians
all FC > 1.2, FDR < 0.05
IFN signaling pathway was the top canonical pathway in South Asians
z score 2.6
P < .001
Further findings
Plasma IFN-γ levels
- Higher plasma IFN-γ in South Asians
- FC = 1.5, FDR = 0.01
Ethnic difference in gene expression by sex
- Genes differing by ethnicity in women
- 20/182 [11%]
- Genes differing by ethnicity in men
- 2/182 [1%]
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →