Prediabetes Is Associated With Increased Risk of Heart Failure Among Patients With Atrial Fibrillation
Main finding · Incident HFResult — go to the resultSubdistribution hazard ratio 1.12 95% CI 1.03–1.22Authors' conclusion
Prediabetes was associated with an increased risk of HF in patients with AF. Compared with patients who remained prediabetic, those who progressed to diabetes at 2 years experienced an increased risk of HF, whereas those who reversed to normoglycemia incurred a lower risk of HF.
Study context
- Population
- Patients newly diagnosed with atrial fibrillation (AF) between 2015 and 2018; mean age 75.5 years, 47% female
- Participants
- 17,943 patients
- Exposure
- Prediabetes vs normoglycemia at baseline
- Prediabetesn = 3,711
- Type 2 diabetesn = 10,127
- Outcome
- Incident heart failure (HF)
- Follow-up
- Median 4.7 years
Methodological detailsFine and Gray competing risks model, death as competing event
- Fine and Gray competing risks model, death as competing event
Main finding
As reported in the abstract
Subdistribution hazard ratio
1.12
95% CI 1.03–1.22
Events by group
Prediabetesvs Normoglycemia
SHR 1.12 (95% CI 1.03–1.22)
Observational data: associations, not effects.
Further findings
| Outcome | SHR (95% CI) | |
|---|---|---|
| HF by change in glycemic status at 2 yearsProgression to diabetesvs Remaining prediabetic | 1.50 (1.13–1.97) | |
| HF by change in glycemic status at 2 yearsReversion to normoglycemiavs Remaining prediabetic | 0.61 (0.42–0.94) | |
| 0.512Subdistribution hazard ratio (log scale) |
Change in glycemic status among baseline prediabetes · 2 years
- Progressed to diabetes
- 403 (11.1%)
- Reversed to normoglycemia
- 311 (8.6%)
Original publication
Prediabetes Is Associated With Increased Risk of Heart Failure Among Patients With Atrial Fibrillation. Diabetes Care. Published 17 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →