Early rhythm control on diabetes-related complications and mortality in patients with type 2 diabetes mellitus and atrial fibrillation
Main finding · Ischemic strokeResult — go to the resultAdjusted hazard ratio 0.77 95 % CI 0.70–0.85Authors' conclusion
Early rhythm control was associated with reduced risks of diabetes-related complications and mortality in subjects with T2DM and AF. Rhythm control within 1 year of AF diagnosis with proper anticoagulation should be considered to prevent adverse outcomes.
Study context
- Population
- Newly diagnosed atrial fibrillation (AF) patients with T2D, Korean National Health Insurance Service claims database 2009–2016; mean age 66.7 ± 10.5 years, 61.8 % men, mean CHA2DS2-VASc 4.6 ± 1.8, mean DM duration 5.6 ± 4.7 years23.1 % received early rhythm control (ERC)
- Participants
- 47,509 participants
- Exposure
- Early rhythm control vs usual care
- Outcome
- Ischemic stroke
- Follow-up
- Mean 4.3 ± 2.3 years
Methodological detailsobservational, nationwide claims database
- Observational
- Nationwide claims database
Main finding
As reported in the abstract
Adjusted hazard ratio
0.77
95 % CI 0.70–0.85
P < 0.001
ERCvs Usual care
aHR 0.77 (95 % CI 0.70–0.85); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95 % CI) | P value | |
|---|---|---|---|
| Macrovascular complications | 0.79 (0.73–0.86) | P < 0.001 | |
| Microvascular complications | 0.86 (0.82–0.90) | P < 0.001 | |
| All-cause death | 0.92 (0.87–0.98) | P = 0.012 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Early rhythm control on diabetes-related complications and mortality in patients with type 2 diabetes mellitus and atrial fibrillation. Diabetes Res Clin Pract. Published 17 November 2023. doi:10.
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