Effect of weight loss on proteinuria in adults with type 2 diabetes: A real-world study
Main finding · UACR regressionResult — go to the resultOdds ratio 1.833 95 % CI 1.262–2.663Authors' conclusion
Our real-world study reveals that weight reduction is associated with UACR regression in patients with T2DM, regardless of the approach used for weight management, and the association was much stronger in males.
Study context
- Population
- Adults with T2D in real-world settings; 44.5 % overweight, 24.1 % obese
- Participants
- 1,054 adults
- Exposure
- Weight loss vs weight gain over one year
- Outcome
- UACR regression (≥30 % reduction), by ordered logistic regression
- Follow-up
- one-year follow-up
Methodological detailsreal-world
- Real-world
Main finding
UACR regression · one year
Odds ratio
1.833
95 % CI 1.262–2.663
P = 0.001
Weight lossvs Weight gain
OR 1.833 (95 % CI 1.262–2.663); P = 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Urinary albumin/creatinine ratio (UACR) regression per 1 kg weight loss
- OR per 1 kg weight loss (6 % UACR regression), 95 % CI 1.02 to 1.10; P = 0.003
- 1.06
Association in subgroups
- Consistent across most subgroups; stronger in males
- P for interaction = 0.023
Proteinuria risk with obesity
- OR for obesity, 95 %CI 1.195 to 2.659
- 1.783
Original publication
Effect of weight loss on proteinuria in adults with type 2 diabetes: A real-world study. Diabetes Res Clin Pract. Published 16 November 2023. doi:10.
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