Association of lipoprotein subfractions with incidence of type 2 diabetes among five U.S. Race and Ethnic groups: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) and Multi-Ethnic study of Atherosclerosis (MESA)
Authors' conclusion
Composition of lipoprotein subfractions is differentially associated with prevalent and incident T2D without difference by race/ethnic group. Assessment of lipoprotein composition may enhance targeted risk reduction for T2D.
Study context
- Population
- Adults self-identifying as White, Black, Chinese, Hispanic and South Asian-American without CVD, with data at enrollment and after 5 years; mean age 62 years, 51 % women3,839 without prevalent diabetes
- Participants
- 4,474 participants
- Comparison
- Lipoprotein subfractions and odds of incident T2D
- Outcome
- Incident T2D
- Follow-up
- 5 years
Methodological detailsMASALA and MESA, multi-ethnic, LASSO regularized logistic regression, adjusted for age, sex, race/ethnicity, lipid-lowering agent use and waist circumference
- MASALA and MESA
- Multi-ethnic
- LASSO regularized logistic regression
- Adjusted for age, sex, race/ethnicity, lipid-lowering agent use and waist circumference
Pooled result
As reported in the abstract
Incident T2D (234 cases)
Triglycerides in small, dense LDL-5: OR (95 % CI 1.11,1.43), higher odds
1.26
VLDL triglycerides: [1.16,1.46], higher odds
1.30
Phospholipids in VLDL-1: OR (1.17,1.47), higher odds
1.31
Free cholesterol in large HDL-1: OR (95 % CI 0.63,0.89), inversely associated
0.75
Further pooled results
Prevalent diabetes; variation by race/ethnic group
- Results similar for prevalent diabetes and did not vary by race/ethnic group
Original publication
Association of lipoprotein subfractions with incidence of type 2 diabetes among five U.S. Race and Ethnic groups: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) and Multi-Ethnic study of Atherosclerosis (MESA). Diabetes Res Clin Pract. Published 28 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →