Adipose tissue-derived metabolite risk scores and risk for type 2 diabetes in South Asians
Authors' conclusion
Metabolite risk scores for intrahepatic fat and visceral fat were strongly related to incident T2D independent of measured adiposity. Use of these biomarkers to target risk stratification may help capture pre-clinical metabolic abnormalities.
Study context
- Population
- South Asians aged 40–84 years without known CVD or T2D, with metabolomic data, Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort; average age 55 years, 36% women, average body mass index (BMI) 25 kg/m², 6% hepatic steatosis
- Participants
- 550 participants
- Exposure
- Metabolite risk scores for hepatic steatosis (MET-Liver) and visceral fat (MET-Visc) and incident T2D
- Outcome
- Incident T2D
- Follow-up
- 5 years
Methodological detailsmetabolomic risk score derivation (elastic net regression), Baseline CT assessed hepatic attenuation and visceral fat area; LC-MS-based untargeted metabolomics; logistic regression adjusted for age, gender, site, BMI, physical activity, diet quality, energy intake and cholesterol-lowering medication
- Metabolomic risk score derivation (elastic net regression)
- Baseline CT assessed hepatic attenuation and visceral fat area; LC-MS-based untargeted metabolomics; logistic regression adjusted for age, gender, site, BMI, physical activity, diet quality, energy intake and cholesterol-lowering medication
Main finding
As reported in the abstract
Incident T2D (47 cases)
MET-Liver and higher odds of T2D, OR
2.04 (1.38, 3.03) (95% CI)
MET-Visc and higher odds of T2D, OR
2.80 (1.75, 4.46) (95% CI)
Observational data: associations, not effects.
Further findings
- Metabolites of known identity
- 445
- Metabolites in MET-Visc score
- 313
- Metabolites in MET-Liver score
- 267
Original publication
Adipose tissue-derived metabolite risk scores and risk for type 2 diabetes in South Asians. Int J Obes (Lond). Published 20 January 2024. doi:10.
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