Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations
Authors' conclusion
Our study improves our understanding of the aetiology of type 2 diabetes in diverse populations.
Study context
- Population
- Multi-Ethnic Study of Atherosclerosis (MESA) participants residing in the USA (genome and plasma proteome data) for protein prediction models; applied to GWAS summary statistics of 250,127 T2D cases and 1,222,941 controls from different racial and ethnic populationsMESA model-building sample
- Participants
- 182 / 69 / 284 / 409
- Comparison
- African vs Asian vs Hispanic/Latino vs European
- Africann = 182
- Asiann = 69
- Hispanic/Latinon = 284
- Europeann = 409
- Outcome
- Proteins associated with T2D risk
Methodological detailsgenetic instruments, multi-ethnic, meta-analysis
- Genetic instruments
- Multi-ethnic
- Meta-analysis
Pooled result
As reported in the abstract
Asian
3 proteins
European
44 proteins
Hispanic/Latino
1 protein
- Meta-analysis: proteins associated with T2D risk across populations, incl. well-established and novel proteins
- 40
Original publication
Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations. Diabetologia. Published 30 September 2024. doi:10.
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