The Association of Inflammatory Factors With Peripheral Neuropathy: The Study of Women's Health Across the Nation
Authors' conclusion
Cardiometabolic factors and inflammation are significantly associated with PN, independent of diabetes and obesity. CRP mediates the relationship of both obesity and MetS with PN, suggesting an etiological role of inflammation in PN in this sample.
Study context
- Population
- Women in the Study of Women's Health Across the Nation, ages 60 to 73 (mean 65.6), assessed for peripheral neuropathy (PN) at follow-up visit 15 (V15)
- Participants
- 1,910 women
- Exposure
- Baseline metabolic syndrome (MetS), obesity, C-reactive protein (CRP) and fibrinogen vs PN symptoms ≈20 years later
- Outcome
- PN symptoms, by symptom questionnaire and monofilament testing
- Follow-up
- V15
Methodological detailslongitudinal, log-binomial regression adjusted for sociodemographic and health behavior measures
- Longitudinal
- Log-binomial regression adjusted for sociodemographic and health behavior measures
Main finding
As reported in the abstract
PN symptoms
Estimate (95% CI)
MetSbaseline MetS
PR 1.79(1.45–2.20)
Obesitybaseline obesity
PR 2.08(1.65–2.61)
CRPmedian CRP
PR 1.32 per log(mg/dL)(1.20–1.45)
Fibrinogenmean fibrinogen
PR 1.28 per 100 mg/dL(1.09–1.50)
Each row per its own increment, as printed
Observational data: associations, not effects.
Further findings
PN, excluding participants with baseline DM or obesity
| Prevalence ratio (CI) | ||
|---|---|---|
| MetS | 1.59 (1.17–2.14) | |
| 0.512Prevalence ratio (log scale) |
| Outcome | Prevalence ratio (per log(mg/dL)) (CI) | |
|---|---|---|
| PN, excluding participants with baseline DM or obesityCRP | 1.19 (1.06–1.35) | |
| 0.512Prevalence ratio (log scale) |
PN, excluding participants with baseline DM or obesity
- MetS and CRP remained statistically significantly associated with PN
Interaction and mediation
- Negative interaction between MetS and obesity
- Association of MetS and obesity with PN mediated by CRP
Original publication
The Association of Inflammatory Factors With Peripheral Neuropathy: The Study of Women's Health Across the Nation. J Clin Endocrinol Metab. Published 19 October 2022. doi:10.
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