The association between inflammation and glucose levels in hospitalised patients with type 2 diabetes
Authors' conclusion
Elevated CRP levels only modestly increased glucose levels. This suggests that inflammation during hospitalisation has a limited effect on glucose levels in non-ICU patients with type 2 diabetes.
Study context
- Population
- Non-ICU hospitalised patients with T2D treated with basal-bolus insulin, managed with rtCGM or point-of-care glucose testingDIATEC trial
- Participants
- 166 participants
- Comparison
- Association of daily C-reactive protein (CRP) with daily glycaemic outcomes and insulin doses
Primary result
As reported in the abstract
Change in TIR 3.9-10.0 mmol/L (70-180 mg/dL) per 100 mg/dL CRP increase: decrease, %-points
3.6
95% CI 1.2–6.1p = 0.004
Change in TIR with interaction of high CRP (>75.0 mg/dL) and high HbA1c (>51.0 mmol/mol or 6.8%): reduction, %-points
8.9
95% CI 3.8–14.1
Change in TAR >10.0 mmol/L (>180 mg/dL) per 100 mg/dL CRP increase: increase, %-points
3.3
95% CI 0.8–5.8p = 0.009
Change in mean glucose per 100 mg/dL CRP increase: increase, mmol/L (95% CI 0.02-0.4)
4.0 mg/dL 0.2
95% CI 0.4–7.0
Original publication
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