Time at High Risk of Hypoglycemia: Validation of a Consensus-Based Continuous Glucose Monitoring-Metric for Hospitalized Patients
Authors' conclusion
The THRH is strongly associated with hypoglycemia in non-ICU hospitalized patients with type 2 diabetes on basal-bolus insulin.
Study context
- Population
- Non-ICU inpatients with T2D on basal-bolus insulin therapy, DIATEC trial
- Participants
- 166 inpatients
- Comparison
- Open continuous glucose monitoring (CGM) vs Point-of-care
- Open CGMn = 84
- Point-of-caren = 82
- Primary endpoint
- Association of time at high risk of hypoglycemia (THRH, 3.9 to 5.6 mmol/L) with TBR (<3.0, 3.0-3.9 and <3.9 mmol/L) and hypoglycemic events
Methodological detailsvalidation study
- Validation study
Primary result
As reported in the abstract
Change in TBR per 10%-point increase in THRH (CGM-monitored patients)
TBR (<3.0 mmol/L): %-point increase (95% CI 0.06-0.21), P < .001
0.13
TBR (3.0-3.9 mmol/L): %-point increase (95% CI 0.47-0.86), P < .001
0.66
TBR (<3.9 mmol/L): %-point increase (95% CI 0.51-0.97), P < .001
0.74
Further findings
- Similar results during day and night analyses and for point-of-care monitored patients, also for hypoglycemic events
Original publication
Time at High Risk of Hypoglycemia: Validation of a Consensus-Based Continuous Glucose Monitoring-Metric for Hospitalized Patients. J Diabetes Sci Technol. Published 11 April 2025. doi:10.
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