Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life
Main finding · Incident T2DResult — go to the resultHazard ratio 0.94 95% CI 0.89–0.99Authors' conclusion
Breastfeeding is associated with a lower risk of incident T2D in offspring, showing both multiplicative and additive interactions with T2D-GRS.
Study context
- Population
- Participants free from prevalent T2D, UK Biobank
- Participants
- 364,562 participants
- Exposure
- Ever breastfed vs never breastfed
- Outcome
- Incident T2D
- Follow-up
- Median 12 years
Methodological detailspopulation-based, UK Biobank, Cox proportional hazards models
- Population-based
- UK Biobank
- Cox proportional hazards models
Main finding
As reported in the abstract
Hazard ratio
0.94
95% CI 0.89–0.99
Ever breastfedvs Never breastfed
HR 0.94 (95% CI 0.89–0.99)
- Incident T2D cases
- 12,795
Observational data: associations, not effects.
Further findings
Interaction of breastfeeding with T2D genetic risk score (T2D-GRS) on T2D risk
- Association of T2D-GRS with T2D stronger in never vs ever breastfed; multiplicative interaction
- p for multiplicative interaction = 0.040
- Risk with never breastfeeding plus high T2D-GRS greater than sum of individual risks; additive interaction
- p for additive interaction = 0.007
Original publication
Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life. Obesity (Silver Spring). Published 23 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →