Correlation of glycosylated apolipoprotein A1 and glycosylated low-density lipoprotein cholesterol levels with glucose homeostasis and the risk of developing type 2 diabetes mellitus
Authors' conclusion
G-apoA1 and G-LDL-C levels are inversely related to pancreatic β-cell function, positively related to insulin resistance, and linked with an increased risk of developing T2DM.
Study context
- Population
- Patients with prediabetes and T2D from two centres
- Participants
- 3,098 patients
- Exposure
- Highest vs lowest quartile of G-apoA1 and glycosylated low-density lipoprotein cholesterol (G-LDL-C)
- Outcome
- Risk of developing T2D by G-apoA1 and G-LDL-C levels
- Follow-up
- 3-year follow-up
Methodological detailstwo-centre, 3-year follow-up
- Two-centre
- 3-year follow-up
Main finding
As reported in the abstract
Developing T2D
Highest quartile vs Lowest quartileHazard ratio (95 % CI)P value
G-apoA1
3.452(2.120–5.768)
P < 0.001G-LDL-C
2.190(1.338–3.578)
P = 0.002- Patients with prediabetes who progressed to T2D
- 197
Observational data: associations, not effects.
Further findings
G-apoA1 and G-LDL-C levels, T2D vs prediabetes
- Levels significantly higher in T2D than in prediabetes
Correlation with HOMA-IR and HOMA-IS
- G-apoA1 and G-LDL-C positively correlated with HOMA-IR and negatively with HOMA-IS
Original publication
Correlation of glycosylated apolipoprotein A1 and glycosylated low-density lipoprotein cholesterol levels with glucose homeostasis and the risk of developing type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 2 April 2025. doi:10.
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