Efficacy and safety of iGlarLixi versus IDegAsp in people with type 2 diabetes inadequately controlled with basal insulin: A systematic literature review and network meta‐analysis of non‐Asian studies
Pooled result · HbA1c reductionResult — go to the resultMD −0.39 %-units 95% CrI −0.58 to −0.21Authors' conclusion
Once-daily iGlarLixi was associated with superior blood glucose control and body weight benefit compared with IDegAsp in insulin-experienced populations with T2D in non-Asian RCTs.
Study context
- Population
- People with T2D previously treated with basal insulin who switched to iGlarLixi or IDegAsp, non-Asian randomized controlled trials (RCTs)
- Participants
- 2,535 people4 RCTs
- Comparison
- iGlarLixi vs IDegAsp
- iGlarLixin = 810
- IDegAspn = 454reference
- Outcome
- HbA1c reduction
Methodological detailsnon-Asian studies, Searched Embase, MEDLINE and CENTRAL on 10 October 2023
- non-Asian studies
- Searched Embase, MEDLINE and CENTRAL on 10 October 2023
Pooled result
As reported in the abstract
MD
−0.39 %-units
95% CrI −0.58 to −0.21
iGlarLixivs IDegAsp
MD −0.39 %-units (95% CrI −0.58 to −0.21)
Further pooled results
| Outcome | Risk ratio (95% CrI) | |
|---|---|---|
| HbA1c <7.0%CrI | 1.42 (1.18–1.71) | |
| 0.512Risk ratio (log scale) |
| Outcome | MD (mmol/L) (95% CrI) | |
|---|---|---|
| Postprandial glucose reductionGreater reduction with iGlarLixi · CrI | −1.38 (−2.15 to −0.63) | |
| −3−2−101Difference, mmol/L (linear scale) |
| Outcome | MD (kg) (95% CrI) | |
|---|---|---|
| Body weightBenefit favoured iGlarLixi · CrI | −1.54 (−2.26 to −0.84) | |
| −3−2−101Difference, kg (linear scale) |
Safety
- Hypoglycaemia evaluation was inconclusive due to definitional differences between trials
Original publication
Efficacy and safety of iGlarLixi versus IDegAsp in people with type 2 diabetes inadequately controlled with basal insulin: A systematic literature review and network meta‐analysis of non‐Asian studies. Diabetes Obes Metab. Published 2 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →