Gestational diabetes & diabetes in pregnancy
Continuous Glucose Monitoring Metrics and Pregnancy Outcomes in Women With Gestational Diabetes Mellitus: A Secondary Analysis of the DiGest Trial
Authors' conclusion
In women with GDM, CGM mean glucose <110 mg/dL (6.1 mmol/L), ≥90% TIRp, or <10% TARp using a range of 63-140 mg/dL (3.5-7.8 mmol/L) at 29 weeks' gestation was associated with a low risk of suboptimal offspring outcomes.
Study context
- Population
- Women with gestational diabetes mellitus (GDM) (diagnosed at median 25.1 weeks) and BMI ≥25 kg/m² receiving a dietary intervention, masked Dexcom G6 continuous glucose monitoring (CGM) at 29, 32 and 36 weeks' gestation361 with CGM at 29 weeks
- Participants
- 425 women
- Comparison
- CGM metric targets achieved vs not achieved at 29 weeks
- Primary endpoint
- Associations of CGM metrics, including TIRp (63-140 mg/dL), with pregnancy outcomes
Methodological detailsmasked CGM, logistic regression, ROC curves and Youden index
- Masked CGM
- Logistic regression
- ROC curves and Youden index
Primary result
As reported in the abstract
29 weeks
- Large for gestational age (LGA), mean glucose <110 mg/dL: OR
- 0.41 (0.22, 0.77) (95% CI)
- LGA, TIRp ≥90%: OR
- 0.38 (0.20, 0.70) (95% CI)
- LGA, TARp <10%: OR
- 0.39 (0.20, 0.73) (95% CI)
- Small for gestational age (SGA), mean glucose <110 mg/dL: OR
- 0.26 (0.08, 0.79) (95% CI)
- SGA, TIRp ≥90%: OR
- 0.30 (0.10, 0.91) (95% CI)
- SGA, TARp <10%: OR
- 0.19 (0.06, 0.62) (95% CI)
Further findings
Preterm birth · 29 weeks
- TARp <10%: OR
- 0.40 (0.17, 0.94)
- Mean nocturnal glucose <110 mg/dL: OR
- 0.42 (0.19, 0.97)
Stricter range (63-120 mg/dL)
- Similar performance overall, but no single statistically robust TIR/TAR target across all outcomes
Original publication
Continuous Glucose Monitoring Metrics and Pregnancy Outcomes in Women With Gestational Diabetes Mellitus: A Secondary Analysis of the DiGest Trial. Diabetes Care. Published 19 August 2025. doi:10.
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