Clinical significance of papillary thyroid carcinoma with solid/trabecular growth
Authors' conclusion
The presence of ST growth was associated with several aggressive clinicopathological features. However, the risk of cancer recurrence and death for PTC-ST were similar to PTC. In the absence of vascular invasion, the clinical impact of ST growth alone is negligible.
Study context
- Population
- Papillary thyroid carcinoma (PTC) patients followed up >5 years, Instituto Português de Oncologia de Lisboa Francisco Gentil, 2002–2020; high-grade carcinomas excludedmedian follow-up 9.3 years
- Participants
- 222 patients
- Exposure
- PTC with solid/trabecular (ST) growth vs PTC without ST growth
- PTC-STn = 74
- PTCn = 148reference
- Outcome
- Tumour characteristics and outcomes, PTC-ST vs PTC
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- PTC-ST vs PTC: P = 0.001
- PTC-ST vs PTC: P < 0.001
- PTC-ST vs PTC: P = 1.000
- PTC-ST vs PTC: P = 0.433
- PTC-ST vs PTC: P = 0.043
- PTC-ST vs PTC: P = 0.347
Observational data: associations, not effects.
Further findings
| Outcome | PTC-ST | P value |
|---|---|---|
| Overall survival · 10 yearsSimilar | 94.6% | P = 0.097 |
| Disease-free survival · 10 yearsSimilar | 98.6% | P = 0.333 |
- Total RAI activity · higher with PTC-ST
- P = 0.008
- Recurrence · similar
- P = 0.755
Risk of death or recurrence
- Distant metastasis increased risk, HR (p < 0.001)
- 10.14
- No evidence of association with presence of ST component (p = 0.201)
Original publication
Clinical significance of papillary thyroid carcinoma with solid/trabecular growth. Clin Endocrinol (Oxf). Published 13 February 2023. doi:10.
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