Prognostic Significance of Detectable Antithyroglobulin Antibodies Based on Analytical Sensitivity in Papillary Thyroid Carcinoma with Undetectable Serum Thyroglobulin after Radioactive Iodine Treatment
Authors' conclusion
TgAb levels above the LOQ were associated with a higher recurrence risk in patients with PTC with undetectable Tg after RAI treatment.
Study context
- Population
- Patients with papillary thyroid carcinoma (PTC) (≥1 cm) with undetectable unstimulated serum thyroglobulin (Tg) (<0.2 ng/mL) 6–12 months after total thyroidectomy with radioactive iodine (RAI) ablation (2009–2012); median age 48.2 years, 18.1% male
- Participants
- 1,039 patients
- Exposure
- Borderline or elevated vs undetectable postoperative TgAb
- Outcome
- Recurrence / 10-year progression-free survival by initial TgAb level
- Follow-up
- Median 12.0 years
Main finding
10-year progression-free survival · 10 years
Adjusted hazard ratio (recurrence)
2.01
CI 1.03–3.96
P = 0.043
By group
Borderlinevs Undetectable
aHR (recurrence) 2.01 (CI 1.03–3.96); P = 0.043
As reported in the abstract
Observational data: associations, not effects.
Further findings
Overall recurrence · median follow-up 12.0 years
- Recurrence
- 4.8%
TgAb course in borderline subgroup · 6.3 years
- TgAb became undetectable in borderline
- 75.0%
- Recurrence rate in those who remained borderline (p = 0.01)
- 12.9%
Original publication
Prognostic Significance of Detectable Antithyroglobulin Antibodies Based on Analytical Sensitivity in Papillary Thyroid Carcinoma with Undetectable Serum Thyroglobulin after Radioactive Iodine Treatment. Thyroid. Published 1 June 2026. doi:10.
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