Ethanol Ablation of Metastatic Lymph Nodes in Patients With Papillary Thyroid Carcinoma—Predictors of Clinical Outcome
Authors' conclusion
EA was highly effective in pure cystic MLNs. Partially cystic or noncystic MLNs over 0.5 mL were less responsive, though many of these MLNs still showed a lasting response. BRAFV600E mutation, aggressive histological subtype, or absence of prior lymph node surgery did not negatively affect EA response.
Study context
- Population
- Patients with PTC and recurrent or persistent metastatic lymph nodes (MLNs) who received ethanol ablation (EA) at a tertiary referral center
- Participants
- 75 patients
- Exposure
- Predictors of long-term response to EA of MLNs: US characteristics, prior lymph node surgery, aggressive histological subtype, BRAFV600E
- Outcome
- Long-term response to EA
Methodological detailssingle-centre, tertiary referral center, BRAFV600E analysis and review of histological subtypes in the primary tumor
- Single-centre
- Tertiary referral center
- BRAFV600E analysis and review of histological subtypes in the primary tumor
Main finding
As reported in the abstract
Pure cystic MLN vs Solid and partially cystic MLN: P = 0.039 · Small MLNs (≤0.5 mL) vs Larger lesions: P = 0.045 · BRAFV600E mutation vs No BRAFV600E mutation: P = 0.181 · Aggressive subtype vs Non-aggressive subtype: P = 0.099
Observational data: associations, not effects.
Further findings
Locoregional disease control by neck region with vs without previous lymph node surgery · similar rates
P = 0.825
Original publication
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