Effect and Interactions of BRAF on Lymph Node Metastasis in Papillary Thyroid Carcinoma With Hashimoto Thyroiditis
Authors' conclusion
BRAF is a risk factor for LN metastasis in PTC with HT. Meanwhile, BRAF can interact with age, BMI, hypertension, and calcification, which together influence LN metastasis.
Study context
- Population
- Papillary thyroid carcinoma (PTC) patients with Hashimoto thyroiditis who underwent surgery, West China Hospital
- Participants
- 994 patients
- Exposure
- BRAF-mutant vs BRAF wild-type
- BRAF-mutantn = 268
- Outcome
- LN metastasis and its risk factors, incl. interaction effect of BRAF
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
LN metastasis
- Overall lymph node (LN) metastasis rate
- 52.71% (524/994)
- Overall BRAF mutation rate
- 26.9% (268/994)
- BRAF mutation rate in LN metastasis vs nonmetastasis patients
- 31.7% vs 21.5%; P < .001
- Risk factors for LN metastasis in all patients: age, body mass index (BMI), hypertension, tumor maximum diameter, BRAF mutation, tumor location, aspect ratio, calcification, extrathyroidal invasion
- P < .05
- Significant interactions between BRAF and BMI, hypertension, maximum diameter and calcification
- P < .05
Observational data: associations, not effects.
Further findings
Risk factors for LN metastasis in BRAF-mutant patients
- Smoking, hypertension, maximum diameter, calcification and multifocality
- P < 0.05
Risk factors for LN metastasis in BRAF wild-type patients
- Age, BMI, maximum diameter, tumor location, aspect ratio, tumor shape, calcification and extrathyroidal invasion
- P < 0.05
Original publication
Effect and Interactions of BRAF on Lymph Node Metastasis in Papillary Thyroid Carcinoma With Hashimoto Thyroiditis. J Clin Endocrinol Metab. Published 15 November 2023. doi:10.
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