Health-Related Quality of Life in Patients with Low-Risk Differentiated Thyroid Cancer: A Systematic Review Examining the Extent of Thyroidectomy
Authors' conclusion
Differences in HRQOL after HT and TT tended to favor HT particularly when measured <6 months after surgery or when compared with TT with CND.
Study context
- Population
- Patients with low-risk differentiated thyroid cancer (DTC) who underwent open thyroid surgery; studies published 2011–202216 studies
- Comparison
- Total thyroidectomy vs hemithyroidectomy
- Outcome
- HRQOL in low-risk DTC survivors after TT vs HT
Methodological details5 prospective and 11 retrospective cohort studies; 14 of good quality; 11 from Asia and the Middle East
- 5 prospective and 11 retrospective cohort studies; 14 of good quality; 11 from Asia and the Middle East
Pooled result
As reported in the abstract
HRQOL, HT vs TT
Studies concluding hemithyroidectomy (HT) led to better health-related quality of life (HRQOL) than total thyroidectomy (TT)
6
Studies concluding HT better only vs TT with central neck dissection (CND)
2
Studies concluding HT better short-term HRQOL, dissipated by 6 months postoperatively
2
Further pooled results
Factors associated with HRQOL in >1 study
- Age, stage and marital status
Original publication
Health-Related Quality of Life in Patients with Low-Risk Differentiated Thyroid Cancer: A Systematic Review Examining the Extent of Thyroidectomy. Thyroid. Published 14 November 2023. doi:10.
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