Mortality among papillary thyroid cancer patients by detection route: a hospital-based retrospective cohort study
Main finding · PTC-specific mortalityResult — go to the resultAdjusted hazard ratio 0.13 95% CI 0.04–0.46Authors' conclusion
Incidental detection is associated with a lower risk of PTC-specific and competing mortality. Under the context of increasing magnitude of overdiagnosis, incorporation of detection route in clinical decision-making might be helpful to identify patients who might benefit from more extensive or conservative therapeutic strategies.
Study context
- Population
- Papillary thyroid cancer (PTC) patients at a cancer center in Guangzhou, baseline 2010–2018
- Participants
- 2,874 patients
- Exposure
- Incidental vs non-incidental detection
- Incidentaln = 2,011
- Outcome
- PTC-specific and competing mortality
Methodological detailshospital-based, single cancer center
- Hospital-based
- Single cancer center
Main finding
PTC-specific mortality · 5 years
Adjusted hazard ratio
0.13
95% CI 0.04–0.46
P = 0.01
By group
Incidentalvs Non-incidental
adjusted HR 0.13 (95% CI 0.04–0.46); P = 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Incidental | Non-incidental | Adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Competing mortality · 5 years | 0.4% | 1.4% | 0.47 (0.20–1.10) | P = 0.10 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Proportion incidentally detected
- Detected incidentally, overall
- 70.0%
- Incidental proportion 2011 to 2018
- 36.9% to 82.3%
Original publication
Mortality among papillary thyroid cancer patients by detection route: a hospital-based retrospective cohort study. Eur Thyroid J. Published 6 November 2023. doi:10.
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