pT1a papillary thyroid carcinomas in pediatric patients
Authors' conclusion
iPTC may be found in 5.1% of pediatric patients undergoing thyroidectomy for benign conditions. Similar to adults, iPTC in pediatric patients appears to be indolent with a minimal risk for invasive features and a low risk for persistent or recurrent disease. In contrast to iPTC, niPTC exhibits the potential for invasive behavior and should be regarded as a distinct entity.
Study context
- Population
- Pediatric patients who underwent thyroidectomy and were diagnosed with pT1a PTC, Children's Hospital of Philadelphia, August 2010–February 2023pT1a PTC cohort
- Participants
- 66 patients
- Exposure
- Incidental PTC vs non-incidental PTC
- Incidental PTC (iPTC)n = 23
- Non-incidental PTC (niPTC)n = 43reference
- Outcome
- Incidence of iPTC in thyroidectomy for benign conditions
Methodological detailsretrospective chart review, single-centre
- Retrospective chart review
- Single-centre
Main finding
As reported in the abstract
iPTC identified in patients undergoing thyroidectomy for benign conditions
23 of 453
5.1%
Observational data: associations, not effects.
Further findings
Greatest dimension · smaller with iPTC
P < 0.001
Lymphatic invasion
P < 0.001
AJCC N1 disease
P < 0.001
ATA pediatric risk category
ATA pediatric low-risk iPTC 22 out of 23 (95.7%)
Intermediate/high-risk niPTC six out of 43 (14.0%)
| Outcome | iPTC | niPTC |
|---|---|---|
| Persistent or recurrent disease · median follow-up 3.3 (iPTC) and 5.7 (niPTC) years | 0 events | — not stated in the abstract |
— not stated in the abstract
- ATA pediatric risk category: iPTC value is low-risk; niPTC value is intermediate/high-risk
Persistent or recurrent disease · median follow-up 3.3 (iPTC) and 5.7 (niPTC) years
- No evidence of persistent or recurrent disease in any patient with iPTC
Original publication
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