Endocrine oncology

Comparable Outcomes of Differentiated Thyroid Cancer in Immunocompromised Versus Immunocompetent Patients

J Clin Endocrinol MetabPublished Retrospective cohort study

Authors' conclusion

DTC has a comparable prognosis in immunocompetent and immunocompromised patients.

Study context

Population
Adults with differentiated thyroid cancer (DTC) treated at Memorial Sloan-Kettering Cancer Center, 1987–2020DTC patients screened
Participants
8,534 adults
Exposure
Immunocompromised vs propensity-matched immunocompetent patients with DTC
  • Immunocompromisedn = 130
  • Immunocompetentn = 650reference
Outcome
Recurrence-free survival
Follow-up
180 months
Methodological detailspropensity-score matched, 5:1 comparison ratio, single-centre
  • Propensity-score matched
  • 5:1 comparison ratio
  • Single-centre

Main finding

As reported in the abstract

  • Recurrence rates below 10% in both cohorts over 180 months
  • Immunocompromised vs Immunocompetent: P = 0.94
  • Propensity-matched cohort

Observational data: associations, not effects.

Further findings

Disease-specific survival · 10 years · similar

P = 0.34

Original publication

Comparable Outcomes of Differentiated Thyroid Cancer in Immunocompromised Versus Immunocompetent Patients. J Clin Endocrinol Metab. Published 7 October 2025. doi:10.1210/clinem/dgaf550

Composed by AI from the published abstract and checked against it. How Briefs are made →

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