A Clinical Nomogram to Predict Survival Outcomes in Patients with Well-Differentiated Thyroid Cancer
Authors' conclusion
We describe a predictive nomogram that accurately predicts DSS in individual patients with WDTC. The external validation illustrates its generalizability.
Study context
- Population
- Patients with well-differentiated thyroid cancer (WDTC) treated with primary surgery
- Participants
- 8,535 vs 519
- Exposure
- Single institutional vs External validation
- Single institutionaln = 8,535
- External validationn = 519
- Outcome
- Disease-specific survival (DSS) prediction by nomogram (concordance index)
Methodological detailssingle institutional, external validation cohort (3 international centres), prognostic nomogram development
- Single institutional
- External validation cohort (3 international centres)
- Prognostic nomogram development
Main finding
As reported in the abstract
Concordance index of the nomogram for DSS
Nomogram created using all these variables: concordance index
0.963; SE 0.012
Nomogram validated on the external patient cohort: concordance index
0.810; SE: 0.070
Observational data: associations, not effects.
Further findings
Predictors of disease-specific survival (DSS) on univariable analysis
- Sex, age, pathology subtype, T stage, N stage and M stage were significant predictors of DSS
Original publication
A Clinical Nomogram to Predict Survival Outcomes in Patients with Well-Differentiated Thyroid Cancer. Thyroid. Published 14 February 2025. doi:10.
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