Nonalcoholic Fatty Liver Disease and the Risk of Thyroid Cancer Among Young Adults in South Korea
Authors' conclusion
NAFLD was associated with an increased risk of thyroid cancer in young adults. Repeatedly elevated FLI and progression of NAFLD were associated with an increased risk of thyroid cancer in this study.
Study context
- Population
- Young adults aged 20 to 39 years who underwent 4 consecutive health screenings in South Korea; Nonalcoholic fatty liver disease (NAFLD) categorized by fatty liver index (FLI)
- Participants
- 1,135,967 adults
- Exposure
- FLI 30 to 60 and FLI ≥60 vs FLI <30
- Outcome
- Incident thyroid cancer
- Follow-up
- Median 5.2 years
Main finding
As reported in the abstract
Thyroid cancer risk
Each group vs FLI <30Hazard ratio (95% CI)
FLI 30 to 60men
1.36(1.22–1.51)
FLI 30 to 60women
1.44(1.21–1.70)
FLI ≥60men
1.71(1.53–1.92)
FLI ≥60women
1.81(1.46–2.25)
- Newly diagnosed with thyroid cancer
- 4126 participants (0.36%)
Observational data: associations, not effects.
Further findings
Cumulative FLI points (number of times FLI ≥30, 0-4)
- Higher cumulative FLI points had higher thyroid cancer risk vs cumulative FLI point of 0
- P < 0.001
Change in FLI during follow-up
- Participants with an increased FLI exhibited an increased risk of thyroid cancer
Original publication
Nonalcoholic Fatty Liver Disease and the Risk of Thyroid Cancer Among Young Adults in South Korea. J Clin Endocrinol Metab. Published 31 October 2023. doi:10.
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