Methylation-Mediated Silencing of ATF3 Promotes Thyroid Cancer Progression by Regulating Prognostic Genes in the MAPK and PI3K/AKT Pathways
Authors' conclusion
We observed that the promoter DNA hypermethylation decreased the expression of ATF3, which in turn promoted the progression of thyroid cancer, at least partially, by directly regulating prognosis-related genes in the MAPK and PI3K/AKT pathways.
Study context
- Population
- Patients with PTC: 80 from the First Affiliated Hospital of Sun Yat-sen University and 510 PTC samples in The Cancer Genome Atlas thyroid cancer database
- Comparison
- Low vs high ATF3 expression in PTC
- Outcome
- ATF3 expression and function in thyroid cancer
Methodological detailsin vitro functional assays, xenograft mouse model, TCGA cohort analysis
- In vitro functional assays
- Xenograft mouse model
- TCGA cohort analysis
Main finding
As reported in the abstract
Low ATF3 expression associated with reduced PFS (adjusted for age, sex, multilocality, extrathyroidal extension, lymph metastases, neoadjuvant treatment history)
aHR = 0.50
CI 0.26–0.98p = 0.043
Original publication
Methylation-Mediated Silencing of ATF3 Promotes Thyroid Cancer Progression by Regulating Prognostic Genes in the MAPK and PI3K/AKT Pathways. Thyroid. Published 27 October 2023. doi:10.
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