The Association Between Thyroid Differentiation Score and Survival Outcomes in Papillary Thyroid Carcinoma
Main finding · PFI by TDSResult — go to the resultAdjusted hazard ratio per TDS (adjusted for overall stage) 0.67 95% CI 0.52–0.85Authors' conclusion
TDS quantifies the spectrum of differentiation status in PTC and may serve as a potential prognostic biomarker in PTC, mostly promisingly in BRAFV600E-mutated tumors.
Study context
- Population
- Patients with papillary thyroid carcinoma (PTC) in two independent cohorts (The Cancer Genome Atlas (TCGA) and MD Anderson Cancer Center (MDACC)); Thyroid differentiation score (TDS) from mRNA expression of 16 genes controlling thyroid metabolism and functiontwo independent cohorts
- Participants
- 372 vs 111
- Exposure
- Higher vs lower thyroid differentiation score
- TCGAn = 372
- MDACCn = 111
- Outcome
- Progression-free interval (PFI)
Methodological detailstwo independent cohorts
- Two independent cohorts
Main finding
PFI by TDS
Adjusted hazard ratio per TDS (adjusted for overall stage)
0.67
95% CI 0.52–0.85
Highervs lower thyroid differentiation score (TDS)
aHR per TDS (adjusted for overall stage) 0.67 (95% CI 0.52–0.85)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Progression-free interval (PFI) in BRAFV600E-mutated tumors, adjusted for overall stage
| aHR (95% CI) | ||
|---|---|---|
| TCGA | 0.60 (0.33–1.07) | |
| MDACC | 0.59 (0.42–0.82) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Overall survival (OS) by TDS, overall MDACC cohort · median follow-up 12.9 years
| aHR (95% CI) | ||
|---|---|---|
| MDACCIncreasing TDS associated with longer OS | 0.78 (0.63–0.96) | |
| 0.512Adjusted hazard ratio (log scale) |
Clinicopathological associations
- In both cohorts, TDS associated with tumor and nodal stage at diagnosis and tumor driver mutation status
Original publication
The Association Between Thyroid Differentiation Score and Survival Outcomes in Papillary Thyroid Carcinoma. J Clin Endocrinol Metab. Published 1 August 2024. doi:10.
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