Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study
Authors' conclusion
This MR study showed that 1-SD increase in genetically predicted height was associated with increased risk of AITD and thyroid cancer. In contrast, there was no evidence of a causal association of genetically predicted AITD with height.
Study context
- Population
- Genetic instruments for height from the largest genome-wide association meta-analysis (up to 5.4 million individuals); summary-level data for autoimmune thyroid disease (AITD) (30,234 cases) and thyroid cancer (3001 cases)
- Comparison
- Genetically predicted height and risk of AITD and thyroid cancer
- Outcome
- AITD and thyroid cancer risk per 1-SD increase in genetically predicted height
Methodological detailsbidirectional mendelian randomization (MR), genetic instruments from genome-wide association meta-analysis
- Bidirectional MR
- Genetic instruments from genome-wide association meta-analysis
Pooled result
As reported in the abstract
Risk per 1-SD increase in genetically predicted height
AITD: increased risk
4%
CI 1.02 to 1.07p-value = 1.99E-03
Thyroid cancer: increased risk
15%
CI 1.07 to 1.23p-value = 2.32E-04
Further pooled results
Reverse causation: AITD on adult height (bidirectional MR)
- No causal association between AITD and adult height
Sensitivity analysis
- Sensitivity analysis confirmed the main results
Original publication
Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study. Thyroid. Published 26 October 2023. doi:10.
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