Causality of Hashimoto's Thyroiditis to Thyroid Cancer: A 2-S Mendelian Randomization Study
Authors' conclusion
This MR analysis indicates a lack of evidence supporting an association between genetically predicted HT and the risk of developing TC. In contrast, there is evidence of a causal relationship between genetically predicted TC and HT.
Study context
- Population
- GWAS data of European and East Asian descent: Hashimoto's thyroiditis (HT) meta-analysis of 756,000 individuals; Thyroid cancer (TC) data set of 1.486 million individuals
- Comparison
- Genetic susceptibility to Hashimoto's thyroiditis (HT) and thyroid cancer (TC), in both directions
- Outcome
- Causal association between HT and TC (bidirectional)
Methodological detailsinverse-variance weighted, sensitivity analyses: MR-Egger, weighted median, MR-PRESSO, leave-one-out
- Inverse-variance weighted
- Sensitivity analyses: MR-Egger, weighted median, MR-PRESSO, leave-one-out
Main finding
As reported in the abstract
Causal relationship between HT and TC
- Genetically predicted HT → TC: no evidence of a causal relationship in European or East Asian populations
- all P > .1
- Genetically predicted TC → HT, European population: OR
- 1.0838; P = .000686 (95% CI as printed: 1.0346, 11 354)
Original publication
Causality of Hashimoto's Thyroiditis to Thyroid Cancer: A 2-S Mendelian Randomization Study. Endocr Pract. Published 18 September 2024. doi:10.
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