Child and adult adiposity and subtype-specific endometrial cancer risk: a multivariable Mendelian randomisation study
Authors' conclusion
As such, child adiposity has an indirect effect on endometrioid EC risk that is mediated by adult adiposity but has a direct effect on non-endometrioid EC risk that is independent of adult adiposity.
Study context
- Population
- Endometrial cancer (EC) cases and controls in the Endometrial Cancer Association Consortium12,906 cases · 108,979 controls
- Comparison
- Genetically proxied child vs adult body size
- Outcome
- EC risk overall and by endometrioid and non-endometrioid histological subtype
Methodological detailsgenetic associations from UK Biobank as proxies
- Genetic associations from UK Biobank as proxies
Main finding
As reported in the abstract
EC risk by subtype (multivariable analyses)
Odds ratio (95% CI)
Adult body sizeoverall EC
2.30(1.73–3.06)
Adult body sizeendometrioid EC
2.28(1.65–3.16)
Child body sizenon-endometrioid EC
2.26(1.03–4.99)
Original publication
Child and adult adiposity and subtype-specific endometrial cancer risk: a multivariable Mendelian randomisation study. Int J Obes (Lond). Published 10 November 2022. doi:10.
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