Comparison of Postoperative Unfavorable Events in Patients with Low-Risk Papillary Thyroid Carcinoma: Immediate Surgery Versus Conversion Surgery Following Active Surveillance
Authors' conclusion
There were no differences in the incidence of unfavorable events between the CS group and the IS group.
Study context
- Population
- Patients clinically diagnosed with low-risk papillary thyroid microcarcinoma at Kuma Hospital, 2005–2019
- Participants
- 242 / 1,739 / 2,896
- Exposure
- Conversion surgery (CS) after active surveillance vs immediate surgery (IS); Active surveillance (AS) vs IS
- CSn = 242
- ISn = 1,739reference
- ASn = 2,896
- Outcome
- Incidence of postoperative unfavorable events after CS vs IS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Unfavorable events (levothyroxine after surgery, postoperative hematoma, transient/persistent hypoparathyroidism, transient/persistent vocal cord paralysis), CS vs IS
- Incidence of unfavorable events did not differ between CS and IS
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Unfavorable events (surgery, levothyroxine, postoperative hematoma, transient/permanent hypoparathyroidism, vocal cord paralysis), IS vs ASSignificantly higher with IS | P < 0.001 |
Lymph node recurrence and overall mortality, AS vs IS
- Distant metastasis or death from thyroid carcinoma in AS and IS
- 0
- No differences between AS and IS
Safety
| Outcome | CS | IS |
|---|---|---|
| Permanent vocal cord paralysis | 0 events | 0.9% |
- Permanent vocal cord paralysis — IS cases caused by accidental injury
- 4
- Permanent vocal cord paralysis — IS cases caused by carcinoma invasion
- 11
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparison of Postoperative Unfavorable Events in Patients with Low-Risk Papillary Thyroid Carcinoma: Immediate Surgery Versus Conversion Surgery Following Active Surveillance. Thyroid. Published 8 November 2022. doi:10.
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