Clinical and ultrasonic risk factors for high‐volume central lymph node metastasis in cN0 papillary thyroid microcarcinoma: A retrospective study and meta‐analysis
Authors' conclusion
Younger age, tumour size >5 mm, males, extrathyroidal extension, multifocality, microcalcification, capsular invasion, and rich blood flow were the significant clinicopathological risk factors for hv-CLNM risk in cN0 PTMC patients. These predictors may compensate for the sensitivity of imaging diagnosis in the preoperative period, thus helping in the effective identification of PTMCs with an invasive phenotype.
Study context
- Population
- Patients with cN0 papillary thyroid microcarcinoma (PTMC) (preoperative cN0, postoperative pathological PTMC); own hospital Jan 2020–Dec 2021 plus studies from Web of Science, PubMed, WANFANG, CNKI to 10 April 202210 studies + 2268 own patients
- Participants
- 14,002 patients
- Comparison
- Clinicopathological and US factors vs high-volume CLNM (hv-CLNM) in cN0 PTMC
- Outcome
- High-volume central lymph node metastasis (CLNM) (>5 lymph nodes)
Methodological detailssingle-centre retrospective cohort pooled with published studies, Statistical analyses with SPSS and MetaXL
- Single-centre retrospective cohort pooled with published studies
- Statistical analyses with SPSS and MetaXL
Pooled result
As reported in the abstract
Risk factors for hv-CLNM
Odds ratio (95% CI)P value
Age <40
3.28(2.75–3.92)
P < 0.001Age <45
2.93(2.31–3.72)
P < 0.001Male sex
2.81(2.25–3.52)
P < 0.001Tumour size >5 mm
1.85(1.39–2.47)
P < 0.001Multifocality
1.88(1.56–2.26)
P < 0.001Extrathyroidal extension
2.58(2.02–3.30)
P < 0.001Capsule invasion
2.02(1.46–2.78)
P < 0.001Microcalcification
3.25(2.42–4.36)
P < 0.001Rich blood flow
1.65(1.21–2.25)
P = 0.002Hashimoto thyroiditis
0.76(0.55–1.07)
P = 0.114Irregular marginvs Regular margin
0.96(0.68–1.33)
P = 0.787Hypoechoicvs Nonhypoechoic
1.27(0.84–1.92)
P = 0.261Original publication
Clinical and ultrasonic risk factors for high‐volume central lymph node metastasis in cN0 papillary thyroid microcarcinoma: A retrospective study and meta‐analysis. Clin Endocrinol (Oxf). Published 3 November 2022. doi:10.
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