Comparison of Patient-Reported Outcomes Between Active Surveillance and Immediate Lobectomy in Patients with Low-Risk Papillary Thyroid Microcarcinoma: Initial Findings from the KoMPASS Cohort
Main finding · QoL scores during follow-upResult — go to the resultβ 0.17 CI 0.02–0.33Authors' conclusion
This study demonstrated that age, tumor size, family history of thyroid cancer, awareness of AS, and income were associated with patients' treatment choices. Although the overall QoL scores were significantly higher in the AS group, the QoL became similar between the two groups after 12 months.
Study context
- Population
- Patients with low-risk papillary thyroid microcarcinoma (PTMC); mean age 47.4 ± 12.2 years, 72.2% women
- Participants
- 927 patients
- Exposure
- Active surveillance (AS) vs immediate lobectomy
- ASn = 453
- Lobectomyn = 474reference
- Outcome
- Factors influencing treatment decision and QoL according to treatment plan
Methodological detailsmulticenter
- Multicenter
Main finding
QoL scores during follow-up · median follow-up 27.3 months (AS) and 28.7 months (Lobectomy)
β
0.17
CI 0.02–0.33
P = 0.029
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | AS | Lobectomy | P value |
|---|---|---|---|
| QoL score at baseline | 7.1 ± 1.2 | 6.7 ± 1.2 | P < 0.001 |
- Quality of life (QoL) score after 12 months
- P = 0.592
Factors associated with choosing AS
- Older age, OR (CI), p
- 1.04 (1.02-1.05), p < 0.001
- Smaller tumor size, OR (CI), p
- 0.78 (0.69-0.87), p < 0.001
- Family history of thyroid cancer, OR (CI), p
- 1.48 (1.03-2.12), p = 0.035
- Prior awareness of AS, OR (CI), p
- 1.53 (1.16-2.02), p = 0.003
- Higher income, OR (CI), p
- 1.79 (1.13-2.83), p = 0.013
QoL score after 12 months
- No significant difference after 12 months
Original publication
Comparison of Patient-Reported Outcomes Between Active Surveillance and Immediate Lobectomy in Patients with Low-Risk Papillary Thyroid Microcarcinoma: Initial Findings from the KoMPASS Cohort. Thyroid. Published 8 October 2024. doi:10.
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