A Temporal Analysis of Surgical Management and Outcomes Following American Thyroid Association (ATA) Guideline Updates in Papillary Thyroid Carcinoma: A Real-World Cohort Study of 31,861 Patients in South Korea
Main finding · Treatment patterns, complications and DFS after ATA guideline updatesResult — go to the resultHR for recurrence 1.520 CI 1.160–1.980Authors' conclusion
ATA guideline-driven de-escalation strategies were successfully implemented in real-world practice in this study, reducing overtreatment and surgical morbidity without compromising short-term oncologic outcomes.
Study context
- Population
- Patients treated for papillary thyroid carcinoma (PTC) ≤4 cm, 2004–2020, high-volume tertiary centre in South Korea
- Participants
- 31,861 patients
- Exposure
- Temporal cohorts before and after ATA guideline updates
- Outcome
- Treatment patterns, complications and DFS after ATA guideline updates
Methodological detailssingle high-volume tertiary centre, exact matching, segmented regression, 5-year restricted mean survival time analysis
- Single high-volume tertiary centre
- Exact matching
- Segmented regression
- 5-year restricted mean survival time analysis
Main finding
As reported in the abstract
HR for recurrence
1.520
CI 1.160–1.980
Triad 2vs Triad 0
HR for recurrence 1.520 (CI 1.160–1.980)
- Recurrence rate lowest in most recent era
- 1.3%
Observational data: associations, not effects.
Safety
- Permanent hypocalcemia decreased from 2.7% to 0.2%
- P < 0.001
- Transient complications remained stable
Original publication
A Temporal Analysis of Surgical Management and Outcomes Following ATA Guideline Updates in Papillary Thyroid Carcinoma: A Real-World Cohort Study of 31,861 Patients in South Korea. Thyroid. Published 9 April 2026. doi:10.
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