The landscape of pediatric differentiated thyroid carcinoma and predictors of invasive disease: a CATC study
Authors' conclusion
Invasive DTC is associated with age <10 years, male sex, tumors driven by oncogenic fusions, and extrathyroidal extension. Despite less aggressive therapies in recent years, disease outcomes have not worsened.
Study context
- Population
- Children (<19 years) with differentiated thyroid carcinoma (DTC) diagnosed 2010–2019, five high-volume pediatric centers; 78.3% female, median age 15.2 years (range 3.2–18.9)
- Participants
- 715 children
- Exposure
- PTC vs Follicular thyroid carcinoma
- PTCn = 673
- Follicular thyroid carcinoman = 42
- Outcome
- Landscape of pediatric DTC and predictors of invasive disease
Methodological detailsinternational, multicenter
- International
- Multicenter
Main finding
As reported in the abstract
PTC stage 1 (M0) disease
562
83.5%; 222 N0, 161 N1a, 179 N1b
Stage 2 (M1) disease in PTC
111
16.5%
Stage 2 (M1) disease in FTC
1 of 42
2.4%
Observational data: associations, not effects.
Further findings
Deintensification of therapy since 2015
- Not associated with changes in disease outcomes
Original publication
The landscape of pediatric differentiated thyroid carcinoma and predictors of invasive disease: a CATC study. J Clin Endocrinol Metab. Published 22 April 2026. doi:10.
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