Procalcitonin Doubling Time for Postoperative Monitoring of Medullary Thyroid Carcinoma: A Comparative Kinetic Analysis
Authors' conclusion
PCT-DT closely mirrors CT-DT and may serve as a complementary kinetic marker in the postoperative monitoring of MTC, particularly when CT interpretation is uncertain
Study context
- Population
- Medullary thyroid carcinoma (MTC) patients followed for up to 24 months after thyroidectomy
- Participants
- 25 patients
- Exposure
- PCT doubling time (PCT-DT) vs calcitonin doubling time (CT-DT)
- Outcome
- Agreement of CT-DT and PCT-DT
Methodological detailslongitudinal, CT and procalcitonin (PCT) measured using Elecsys immunoassays, DTs estimated by log-linear regression and rolling-window approach
- Longitudinal
- CT and PCT measured using Elecsys immunoassays
- DTs estimated by log-linear regression and rolling-window approach
Main finding
As reported in the abstract
Categorical agreement in progressive disease (Cohen's κ), substantial
κ = 0.76
Observational data: associations, not effects.
Original publication
Procalcitonin Doubling Time for Postoperative Monitoring of Medullary Thyroid Carcinoma: A Comparative Kinetic Analysis. Clin Endocrinol (Oxf). Published 21 April 2026. doi:10.
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